Bazirgan, O.A., Garza, R.M., Hampton, R. Y. 2006. Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase. Journal of Biological Chemistry EPub:ahead of print. PDF (2.0Mb)

Sato, B.K., Hampton, R. Y. 2006. Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis. Yeast 23:1053-1064. PDF (843K)

Hampton, R. Y. 2005. Fusion-based strategies to identify genes involved in degradation of a specific substrate. Methods in Enzymology 399:310-323. PDF (119K)

Flury, I., Garza, R.M., Shearer, A.G., Rosen, J., Cronin, S. Hampton, R. Y. 2005. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. EMBO Journal 24:3917-3926. PDF (456K)

Federovitch, C.M., Ron, D., Hampton, R. Y. 2005. The dynamic ER: experimental approaches and current questions. Current Opinions in Cell Biology 17:409-414. PDF (308K)

Garza, R.M., Hampton, R. Y. 2005. Cell biology: sterol sensor comes up for air. Nature 435:37-38. PDF (188K)

Bazirgan, O.A., Hampton, R. Y. 2005. Cdc48-Ufd2-Rad23: the road less ubiquitinated? Nature Cell Biology 7:207-209. PDF (284K)

Shearer, A.G., Hampton, R. Y. 2005. Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. EMBO Journal 24:149-159. PDF (304K)

Ron, D, Hampton, R. Y. 2004. Membrane biogenesis and the unfolded protein response. Journal of Cell Biology 167:23-25. PDF (96K)

Shearer, A.G., Hampton, R. Y. 2004. Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase. Journal of Biological Chemistry 279:188-196. PDF (384K)

Hampton, R. Y. 2003. IRE1: a role in UPREgulation of ER degradation. Developmental Cell 4:144-146. PDF 92K)

Hampton, R. Y. 2002. ER-associated degradation in protein quality control and cellular regulation. Current Opinions in Cell Biology 14:476-482. PDF (188K)

Hampton, R. Y. 2002. Proteolysis and Sterol Regulation. Annual Reviews of Cell and Developmental Biology 18:345-78. PDF (464K)

Bays, NW, Hampton RY. 2002. Cdc48-ufd1-np14: stuck in the middle with ub. Current Biology 12: R366-71. PDF (488K)

Cronin, S. R., Rao, R., Hampton, R. Y. 2002. Cod1p/Spf1p is a P-type ATPase involved in ER function and CA2+ homeostasis. Journal of Cell Biology 157:1017-1028. PDF (476K)

Bays, N. W., Wilhovsky, S. K., Goradia, A., Hodgkis-Harlow, K., Hampton, R. Y. 2001. HRD4/NPL4 Is Required for the Proteasomal Processing of Ubiquitinated ER Proteins. Molecular Biology of the Cell 12:4114-28. PDF (692K)

Gardner RG, Shearer AG, Hampton RY. 2001. In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Molecular Cell Biology 21:4276-91. PDF (840K)

Gardner, R., Shan, H., Matsuda, S., and R. Hampton. 2001. An oxysterol-derived positive signal for 3-hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. Journal of Biological Chemistry 276: 8681-8684. PDF (652K)

Bays, N., Gardner, R., Seelig, L., Joazeiro, C., and R. Hampton. 2001. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nature Cell Biology 3:24-29. PDF (355K)

Gardner, R., Swarbrick, G., Bays, N., Cronin, S., Wilhovsky, S., Seelig, L., Kim, C., and R. Hampton. 2000. Endoplasmic reticulum degradation requires lumen to cytosol signaling: transmembrane control of Hrd1p by Hrd3p. Journal of Cell Biology 151:69-82. Full Text PDF (688K)

Wilhovsky, S., Gardner, R., and R. Hampton. 2000. HRD gene dependence of endoplasmic reticulum degradation. Molecular Biology of the Cell 11:1697-1708. Full Text PDF (428K)

R. Hampton. 2000. ER stress response: getting the UPR hand on misfolded proteins. Current Biology 10:R518-521. Full Text

R. Hampton. 2000. Cholesterol homeostasis: ESCAPe from the ER. Current Biology 10:R298-301. Full Text PDF

Cronin, S., Khoury, A., Ferry, D., and R. Hampton. 2000. Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. Journal of Cell Biology 148:915-924. Full Text PDF (324K)

Gardner, R. and R. Hampton. 1999. A 'distributed degron' allows regulated entry into the ER degradation pathway. Embo 18:5994-6004. Full Text PDF (332K)

Gardner, R. and R. Hampton. 1999. A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes. Journal of Biological Chemistry 274:31671-31678. Full Text PDF (353K)

Gardner, R., Cronin, S., Leder, B., Rine, J., and R. Hampton. 1998. Sequence determinants for regulated degradation of yeast 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Molecular Biology of the Cell 9:2611-2626. Full Text PDF (553K)

Hampton, R. and H. Bhakta. 1997. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase. Proc. Natl. Acad. Sci. USA 94:12944-12948. Full Text PDF (314K)

Hampton, R., Gardner, R., and J. Rine. 1996. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein. Mol.Biol. Cell 7:2029-2044. Abstract

Hampton, R, Dimster-Demk. D., and J. Rine. 1996. The biology of HMG-CoA reductase: The pros of contra-regulation. Trends Biochem. Sci. 21:142-145.

Hampton, R., Koning, A., Wright, R., and J. Rine. 1996. In vivo examination of membrane protein localization and degradation with green fluorescent protein. Proc. Natl. Acad.Sci. USA 93 (2):828-33.

Hampton, R. and J. Rine. 1994. Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast. J. of Cell Biology 125: 299-312.